Int J Burn Trauma 2012;2(2):118-125

Original Article
Comparision of clinical and histopathological results  of hyalomatrix usage in
adult patients

Serkan Erbatur, Yusuf Kenan Coban, Engin Nasuhi Aydın

Plastic Reconstructive and Aesthetic Surgery department, Medical Faculty, Inonu University, Malatya-Turkey; Plastic
Reconstructive and Aesthetic Surgery department, Medical Faculty, Inonu University, Malatya-Turkey; Department of Pathology,
Medical Faculty, Inonu University, Malatya-Turkey

Received August 28, 2012; Accepted September 15, 2012; Epub September 17, 2012; Published September 30, 2012

Abstract: Clinical and histopathological results of the hyaluronic acid skin substitute treatment of the patients who admitted to
Inonu University Medical Faculty Plastic Reconstructive and Aesthetic Surgery clinic between january 2011 and march 2012
were evaluated. The patients were divided into two groups. HA were used for treatment of Hypertrophic scar (HS) or Keloid (K)
in 10 patients of the first group. Skin biopsies obtained at peroperative and postoperative 3rd month were subjected to
histopathologic examination in this group. In the second group, 10 patients with full thickness soft tissue loss secondary to
burns, trauma or excisional reasons were also treated with HA application. Vancouver scar scale were used to determine the
scar quality in both groups. Mean age was 25. 2 ± 10.2 and mean follow-up duration was 6.3±3.6 months in group 1.
Preoperative and postoperative VSS scores in group 1 were 10.7±1.16 and 6.2±0.91, respectively. This difference was
statistically significant (p<0,005). No HS or K development was seen in any patient in group 2 during the following period.
Collagenisation scores of preoperative skin biopsies were significantly higher than postoperative scores (p<0,0001).
Vascularisation scores of preoperative skin biopsies were significantly lower than postoperative scores (p<0,00001). The use
of HA skin substitute in adults for treatment of HS or K provided the desired clinical healing in the 6 months’ follow-up periods.
At the same time, HA application as an alternative to other treatment modalities led to a durable skin coverage in full thickness
tissue loss in adult patients. (IJBT1208004).

Keywords: Hypertrophic scar, hyalomatrix, wound healing


Address correspondence to:
Dr. Yusuf Kenan Coban
Plastic Reconstructive and Aesthetic Surgery department
Medical Faculty, Inonu University, Malatya-Turkey.
Tel: +904222374780
E-mail: ykenanc@yahoo.com
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